The science of hair loss

DHT & Androgenetic Alopecia

The most common cause of hair loss in both men and women. DHT — a hormone derived from testosterone — gradually miniaturises genetically susceptible follicles until they stop producing hair entirely.

95%
of male hair loss is DHT-driven
50%
of women affected by 50
Treatable
with proven options

How DHT destroys follicles

1
Testosterone is converted to DHT by the enzyme 5-alpha reductase in the skin and hair follicles
2
DHT binds to androgen receptors in genetically susceptible follicles
3
The growth phase (anagen) shortens progressively with each hair cycle — hairs become finer and shorter
4
The follicle eventually miniaturises completely — producing vellus (peach fuzz) hair only
5
Without intervention, the follicle becomes permanently dormant and stops producing hair
The back and sides of the scalp are DHT-resistant — which is why they are used as donor areas in FUE.
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GMC: 4369286Dr Anzal Qurbain
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FFPM QualifiedPharmacological expertise
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19 Harley StreetHospital setting
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Free assessmentPersonal reply from DrQ
Understanding androgenetic alopecia

Pattern hair loss explained

Androgenetic alopecia — commonly called male pattern baldness in men and female pattern hair loss in women — is a genetic condition in which hair follicles in specific scalp zones are programmed to be sensitive to DHT.

It is not caused by wearing hats, poor circulation, or washing hair too often. The cause is genetic DHT sensitivity — inherited from either parent, not just the maternal line as is commonly believed.

In men, loss follows the Norwood scale — typically beginning at the temples and crown. In women, loss follows the Ludwig scale — diffuse thinning across the crown with hairline preservation.

⚠️ Donor area immunity is why FUE works

The back and sides of the scalp contain follicles that are genetically resistant to DHT. When transplanted, these follicles retain their DHT-resistant characteristics in the new location — which is why well-performed FUE results are permanent.

In men
▸Begins with temporal recession (Norwood 2–3)
▸Progresses to crown thinning and eventual merging of recession zones
▸Rate varies — some men progress rapidly in their 20s, others slowly over decades
▸Finasteride and minoxidil are first-line medical options
In women
▸Typically presents as diffuse thinning across the crown (Ludwig scale)
▸Frontal hairline usually preserved — unlike male pattern
▸Often triggered or accelerated by menopause, post-partum, or hormonal change
▸Minoxidil is first-line; finasteride only in post-menopausal women
5α-reductase
converts testosterone to DHT
60-70%
DHT reduction with finasteride 1mg daily
Inherited
follicle sensitivity is genetic, not lifestyle
Medical treatment

DHT-blocking and hair growth medications

Medical treatment works best when started early — before significant follicle miniaturisation has occurred. Dr Qurbain's FFPM qualification means he brings deep pharmacological expertise to medication discussions that most hair clinics cannot offer.

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DHT blocker — oral

Finasteride (Propecia)

Inhibits 5-alpha reductase type II, reducing scalp DHT by approximately 70%. Proven to slow progression and stimulate regrowth in most men. Requires ongoing use — stopping reverses benefit within 12 months.

Not suitable for women of childbearing age. Post-menopausal women may be considered.

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DHT blocker — oral (stronger)

Dutasteride (Avodart)

Inhibits both type I and type II 5-alpha reductase, reducing scalp DHT by over 90%. More potent than finasteride. Used off-label for hair loss — discussed at consultation for suitable candidates.

Greater DHT suppression, similar side effect profile to finasteride.

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Hair growth — topical or oral

Minoxidil

Extends the anagen (growth) phase and increases follicle size. Works independently of DHT — effective in both men and women. Available as 5% topical or low-dose oral (0.25–1.25mg daily).

Oral minoxidil increasingly preferred for compliance and systemic effect.

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Growth factor therapy

PRP (Platelet-Rich Plasma)

Concentrated platelets from your own blood injected into the scalp release growth factors that stimulate miniaturised follicles. Best used alongside medical treatment, not as a standalone.

Typically 3 sessions initially, then 6–12 monthly maintenance.

Surgical restoration

When is FUE the right option?

FUE hair transplant restores areas of permanent follicle loss using DHT-resistant donor follicles from the back and sides of the scalp. It does not stop ongoing DHT-driven loss in untreated areas — which is why medical treatment and surgical planning must be considered together.

✓ Good FUE candidate
✓Stable hair loss for 12+ months
✓Realistic about future progression
✓Sufficient DHT-resistant donor supply
✓Willing to continue medical treatment post-surgery
✓Good general health
✕ Caution needed
✕Active ongoing progression without medical treatment
✕Very young (under 25) with rapidly progressing loss
✕Insufficient donor density for required coverage
✕Unrealistic expectations about density achievable
✕Unwilling to address ongoing DHT-driven loss medically
FAQ

DHT and hair loss — your questions answered

Can I lower DHT naturally?
Some lifestyle factors influence DHT levels — reducing chronic stress, maintaining a healthy weight, and limiting alcohol can modestly reduce circulating androgens. However, natural reductions are typically insufficient to meaningfully slow genetically driven follicle miniaturisation. Medical DHT blockers (finasteride, dutasteride) are far more effective.
Do I need to take finasteride forever?
Yes, for sustained benefit. Finasteride works by continuously suppressing DHT. Stopping treatment reverses its protective effect within 9–12 months, and previously slowed or reversed loss will resume. Many men take it long-term without significant side effects.
Will a hair transplant stop DHT from causing more loss?
No — a transplant replaces lost hair with DHT-resistant grafts from the donor area. But if you have DHT-sensitive native hair that has not yet been lost, that hair can continue to thin without medical treatment. This is why combining FUE with ongoing medical treatment produces the best long-term results.
Are transplanted hairs resistant to DHT?
Yes — because they come from the DHT-resistant zone at the back and sides of the scalp. Follicles retain the genetic characteristics of their original location even after transplantation. Well-placed FUE grafts are considered permanent.
I'm in my 20s and losing hair fast — what should I do?
Start medical treatment as soon as possible to slow progression and protect existing follicles. Early intervention with finasteride and minoxidil is significantly more effective than waiting. Surgery is generally deferred until the pattern has stabilised — typically mid to late 20s at earliest — to avoid transplanting into an area that will continue to thin around the grafts.
Does DHT affect women the same way?
Yes, but the pattern and severity differ. Women have lower testosterone and higher oestrogen, which moderates DHT's effect. Female pattern hair loss typically presents as diffuse thinning across the crown rather than recession. Finasteride is not used in pre-menopausal women; minoxidil is the primary medical option.
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